The objective of the study was to investigate the effect of isatin against cisplatin-induced nephrotoxicity in male albino rats. Nephrotoxicity was induced by intra peritoneal administration of cisplatin (6 mg/kg body wt, i.p). Isatin was administered by gastric intubation. Animals were divided into 5 groups, each group containing 6 animals, group I animals received vehicle (1% CMC), group II animals received cisplatin on day 1, group III received 400 mg /kg body weight isatin for 10 days, group IV and V received 200 mg/kg and 400 mg/kg body weight isatin respectively. From day 1 to day 10 and on day 5 these groups received cisplatin. On day 9 urine was collected and urinary functional parameters were estimated on day 10 blood was collected BUN, SC were estimated. Cisplatin caused acute renal damage characterized by elevation of BUN, SC. Animals received isatin reversed all the effects induced by cisplatin in dose dependent manner. Present study reveals that isatin attenuated the nephrotoxicity of cisplatin in rats.
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